Wei Yue, Ph.D.

---

Summary

My research program focuses on studying novel mechanisms involved in regulation of OATP1B1 and OATP1B3 transport function. The long-term goal of my laboratory is to establish a mechanistic model to predict OATP-mediated drug-drug interactions, toxicities and inter-individual variability in drug response. Multi-disciplinary approaches are utilized including: 1) Sandwich-cultured primary human hepatocytes model; 2) Physiologically based pharmacokinetic (PBPK) modeling approach to assess clinically relevant DDIs; 3) Pharmacogenomics studies of drug transport proteins; 4) Post-translational regulation of OATP transporters; 5) Confocal microscopy to study trafficking of the transport proteins.

Academic Awards

---

Publications & Presentations

1. Aditya V, Kayesh R, Ballesteros-Perez A, Xu C, Soderblom E, Yue W. Increased Lysine Acetylation Following PKC Activation Reduces OATP1B1 Transport Function. 2026

2. Aditya V, Tambe V, Niyonshuti P, Kayesh R, Soderblom E, Xu C, Yue W. Regulation of OATP1B1 Transport Function by Lysine Acetylation and Lysine Deacetylase 6. Molecular Pharmacology. 2026

3. Tambe V, Niyonshuti P, Aditya V, Hays F A, Kayesh R, Soderblom E J, Xu C, Yue W. Post-translational regulation of organic anion transporting polypeptide 1B3 transport function by lysine acetylation and lysine deacetylase 6 inhibition. Drug Metabolism and Disposition. 2026

4. Aditya V, Tambe V, Yue W. Development of a Novel Automated Workflow in Fiji ImageJ for Batch Analysis of Confocal Imaging Data to Quantify Protein Colocalization Using Manders Coefficient. Bio Protocol. 2025; 15 : e5285

5. Tambe V, Soderblom E J, Kayesh R, Aditya V, Xu C, Yue W. Regulation of organic anion transporting polypeptide 1B1 transport function by concurrent phosphorylation and lysine-acetylation: A novel posttranslational regulation mechanism. Molecular Pharmacology. 2025; 107 : 100007

Grants

1. Regulation of Hepatic Drug Transport Proteins: Identifying Novel Drug Interaction Signals. NIH. Start Date: 2026. End Date: 2031.

2. Regulation of organic cation transporter 1 transport function by lysine deacetylase 6: implications in drug-nutrient interactions. Non-federal. Start Date: 2025. End Date: 2026.

3. Regulation of Hepatic Drug Transport Proteins: Identifying Novel Drug Interaction Signals. Misc Non-Federal. Start Date: 2026. End Date: 2026.

4. Equipment supplement award-Regulation of OATP1B1 and OATP1B3 by lysine acetylation and lysine deacetylase inhibitors . NIH. Start Date: 2024. End Date: 2026.

5. Regulation of OATP1B1 and OATP1B3 by lysine acetylation and lysine deacetylase inhibitors . NIH. Start Date: 2022. End Date: 2026.

Awards and Honors

1. OUHSC. Anadarko Foundation Presidential Professorship. Date: 2026.


2. ASPET. ASPET Faculty Scholars. Date: 2025.


3. OUHSC. Regents’ Award for Superior Teaching. Date: 2024.


4. WiSDMH at OUHSC. Recognition of OUHSC Women in Science Dentistry Medicine and Health. Date: 2022.


5. OUHSC. Member of Educators for Excellence of OUHSC. Date: 2022.

Education

1. Degree: Postdoctoral training. Eshelman School of Pharmacy, University of North Carolina at Chapel Hill. Date: 2008.


2. Degree: Postdoctoral Training. Lineberger Comprehensive Cancer Center, Univeristy of North Carolina at Chapel Hill. Date: 2007.


3. Degree: Ph D. Peking Union Medical College and Shandong University, China. Date: 2001.


4. Degree: MS. Shandong University, China. Date: 1998.


5. Degree: BS. Shandong Agricultural University, China. Date: 1995.

Administrative Assignments

no results